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Molecular cytogenetic analysis of a complex t(10;22;11) translocation in Ewing's sarcoma
F Speleman1, N Van Roy, J Wiegant
1Department of Medical Genetics, University Hospital, Ghent, Belgium.
Genes, Chromosomes & Cancer
|March 1, 1992
Abstract:
Fluorescence in situ hybridization (FISH) using chromosome-specific plasmid libraries and chromosome region-specific DNA markers allowed the characterization of a t(10;22;11) (p11.2;q12;q24) in a Ewing's sarcoma (ES). This study illustrates the usefulness of molecular cytogenetic analysis of ES, especially for determining the localization of the translocated 11q24-25 segment in complex or variant translocations.