Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium currents in hearts with persistent truncus arteriosus.

S Aiba1, T L Creazzo

  • 1Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta 30912-2000.

The American Journal of Physiology
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of IκBζ Drives Dentin Formation via Altered H3K4me3 Status.

Journal of dental research·2022
Same author

A retrospective study evaluating the outcomes of high-dose methylprednisolone pulse therapy for 483 patients with moderate-to-severe alopecia areata.

The British journal of dermatology·2021
Same author

Immune checkpoint inhibitor-induced vitiligo in advanced melanoma could be related to increased levels of CCL19.

The British journal of dermatology·2019
Same author

Three patients with advanced cutaneous angiosarcoma treated with eribulin: investigation of serum soluble CD163 and chemokine (C-X-C motif) ligand 10 as possible biomarkers predicting the biological behaviour of angiosarcoma.

The British journal of dermatology·2018
Same author

Comparison of the measuring efficacy of transepidermal water loss of a reasonably priced, portable closed-chamber system device H4500 with that of rather expensive, conventional devices such as Tewameter<sup>®</sup> and Vapometer<sup>®</sup>.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2017
Same author

Soil phosphorus fractionation and phosphorus-use efficiencies of tropical rainforests along altitudinal gradients of Mount Kinabalu, Borneo.

Oecologia·2017

Defective heart development in embryonic chicks with persistent truncus arteriosus (PTA) significantly reduced L-type calcium currents (ICa,L) in ventricular myocytes. T-type calcium currents (ICa,T) remained unaffected, suggesting altered channel function in congenital heart disease.

Area of Science:

  • Cardiovascular Physiology
  • Developmental Biology
  • Molecular Cardiology

Background:

  • Congenital heart defects, such as persistent truncus arteriosus (PTA), arise from complex developmental disruptions.
  • Neural crest cells play a critical role in embryonic heart formation, and their dysfunction can lead to anomalies like PTA.
  • Calcium currents (ICa,L and ICa,T) are essential for cardiac myocyte function and development.

Purpose of the Study:

  • To investigate the impact of persistent truncus arteriosus (PTA) on L-type (ICa,L) and T-type (ICa,T) calcium currents in embryonic chick ventricular myocytes.
  • To utilize a neural crest cell-based model to study calcium channel function in a congenital heart defect.

Main Methods:

  • Electrophysiological characterization of ICa,L and ICa,T in ventricular myocytes from embryonic chick hearts with PTA.

Related Experiment Videos

  • Comparison of calcium current properties between hearts with PTA and sham-operated controls.
  • Analysis of ventricle-to-whole embryo weight ratios as an indicator of developmental impact.

    • Main Results:

    • Hearts with PTA exhibited a 61% larger ventricle-to-whole embryo weight ratio.
    • A 51% reduction in the peak magnitude of ICa,L was observed in PTA hearts, while ICa,T remained unchanged.
    • Dihydropyridine receptor binding suggested no change in total L-type calcium channels, implying reduced functional channels or conductance.

    Conclusions:

    • Persistent truncus arteriosus (PTA) is associated with a significant reduction in functional L-type calcium channels in embryonic chick ventricular myocytes.
    • T-type calcium currents are not affected by PTA, indicating a specific impact on L-type channels.
    • The study suggests that altered calcium channel function, rather than innervation, is a key factor in PTA-related cardiac developmental defects.