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Related Experiment Videos

Interferon-alpha in lupus psychosis.

S Shiozawa1, Y Kuroki, M Kim

  • 1Department of Medicine, Kobe University Hospital, Japan.

Arthritis and Rheumatism
|April 1, 1992
PubMed
Summary

Interferon-alpha (IFN alpha) in cerebrospinal fluid (CSF) is linked to neuropsychiatric lupus psychosis. Elevated IFN alpha in the brain suggests it causes psychosis in systemic lupus erythematosus (SLE) patients.

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Area of Science:

  • Neuroimmunology
  • Systemic Lupus Erythematosus (SLE) Pathogenesis

Background:

  • Elevated serum interferon-alpha (IFN alpha) is observed in active systemic lupus erythematosus (SLE).
  • IFN alpha is detectable in the cerebrospinal fluid (CSF) of some SLE patients with neuropsychiatric symptoms.

Purpose of the Study:

  • To investigate the role of IFN alpha in the pathogenesis of neuropsychiatric manifestations in SLE.
  • To determine if IFN alpha contributes to lupus psychosis.

Main Methods:

  • Quantification of IFN alpha levels in CSF and serum using radio-immunoassay.
  • Analysis of samples from 17 SLE patients with neuropsychiatric manifestations and 28 SLE patients without or with other neurological disorders.
  • Immunohistochemical analysis of brain tissue from a deceased lupus psychosis patient.

Main Results:

  • Increased IFN alpha levels were found in the CSF of 5 out of 6 patients with lupus psychosis, often higher than serum levels.
  • IFN alpha levels decreased as lupus psychosis symptoms subsided.
  • IFN alpha protein was detected in the neurons and microglia of the brain in a patient with lupus psychosis, but not in control subjects.

Conclusions:

  • Findings support the hypothesis that IFN alpha contributes to lupus psychosis in SLE patients.
  • IFN alpha may be synthesized within the brain, directly causing psychosis.

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