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In vivo modulation of myelin gene expression by human recombinant IL-2
M Sessa1, R Nemni, S Iannaccone
1Department of Neurology, University of Milan, IRCCS Hospital San Raffaele, Italy.
Brain Research. Molecular Brain Research
|February 1, 1992
Abstract:
We treated adult mice with human recombinant interleukin-2 (IL-2) and determined the expression of the genes encoding for the major central and peripheral myelin proteins. In the CNS, myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) mRNA levels were the same both in IL-2-treated and in control mice. Proteolipid protein (PLP) transcript was decreased in IL-2-treated animals when compared to controls. In the PNS, the messages for the glycoprotein P0 and for MBP were markedly increased in IL-2-treated animals when compared to controls.