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Related Experiment Videos

Is the multidrug transporter a flippase?

C F Higgins1, M M Gottesman

  • 1Imperial Cancer Research Fund Laboratories, University of Oxford, John Radcliffe Hospital, UK.

Trends in Biochemical Sciences
|January 1, 1992
PubMed
Summary
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Multidrug resistance involves P-glycoprotein, a membrane protein that removes drugs from cells. This study proposes P-glycoprotein acts as a flippase, transporting drugs across the cell membrane to reduce toxicity.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Pharmacology

Background:

  • Multidrug resistance (MDR) is a major challenge in medicine.
  • P-glycoprotein (P-gp) is a key membrane protein implicated in MDR.
  • The precise mechanism of P-gp drug efflux remains poorly understood.

Purpose of the Study:

  • To propose a novel mechanism for P-glycoprotein's function in multidrug resistance.
  • To explain the properties of multidrug transporters based on a proposed mechanism.

Main Methods:

  • This study is theoretical, proposing a mechanism based on existing knowledge.
  • It involves analyzing the biophysical and biochemical properties of P-glycoprotein.

Main Results:

Related Experiment Videos

  • The study suggests P-glycoprotein functions as a 'flippase'.
  • This flippase model explains how P-gp transports diverse drugs across the cell membrane.
  • The proposed mechanism accounts for P-gp's role in reducing drug toxicity.

    • Conclusions:

    • P-glycoprotein's drug efflux mechanism can be explained by its action as a lipid bilayer flippase.
    • This flippase model provides a new perspective on multidrug resistance.
    • Understanding this mechanism may lead to strategies to overcome drug resistance.