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Effect of recombinant human granulocyte colony-stimulating factor on survival in lethally irradiated mice

Y Hosoi¹, A Kurishita, T Ono

¹Department of Radiation Research, Tohoku University School of Medicine, Sendai, Japan.

Acta Oncologica (Stockholm, Sweden)

|January 1, 1992

Abstract:

Repeated injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF) to lethally irradiated mice increased the rate of animal survival. Dose modification factor was 1.20 when 4.5 micrograms/mouse of rhG-CSF was given daily for 14 days after whole body irradiation. Haematological examinations revealed that rhG-CSF increased the number of blood-circulating leukocytes, neutrophils, monocytes and erythrocytes, but not that of lymphocytes and thrombocytes. Spleen weight and number of endogenous spleen colonies were also increased by rhG-CSF treatment compared with the values for mice irradiated only.

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