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Related Experiment Videos

Chromium in the elderly.

E G Offenbacher1

  • 1Department of Medicine, St. Luke's-Roosevelt Hospital, Columbia University, New York, NY 10025.

Biological Trace Element Research
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Chromium (Cr) supplementation may benefit elderly health, but results vary. Aging might decrease chromium retention and alter metabolism, potentially requiring higher intake during illness.

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Area of Science:

  • Nutrition Science
  • Gerontology
  • Biochemistry

Background:

  • Conflicting study results exist regarding chromium (Cr) supplementation effects on glucose tolerance and lipid levels in the elderly.
  • Previous research is limited by the lack of a Cr deficiency marker, inadequate analytical techniques, and confounding factors like health status and medications.

Purpose of the Study:

  • To investigate the effects of aging on chromium (Cr) metabolism and retention in the body.
  • To assess potential alterations in chromium levels and losses due to the aging process.

Main Methods:

  • Review of existing studies on Cr supplementation and aging.
  • Analysis of animal models (rats) to observe age-related changes in Cr tissue retention and distribution.
  • Comparison of plasma Cr levels between healthy elderly and young adult humans.

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  • Assessment of urinary Cr losses in elderly individuals.

    • Main Results:

    • Aging in rats shows decreased tissue retention and altered organ distribution of 51Cr.
    • Plasma Cr levels in healthy elderly humans are comparable to young adults.
    • No evidence of malabsorption in aged humans or animals was found.
    • Elderly individuals exhibit higher urinary Cr losses, suggesting decreased Cr retention with age.
    • Dietary Cr intake for many elderly individuals is below 30 micrograms/day, potentially insufficient during illness.

    Conclusions:

    • Aging may decrease chromium retention and alter chromium metabolism.
    • Higher urinary Cr losses in the elderly suggest reduced Cr retention.
    • Recommended dietary intake levels may be insufficient for the elderly, especially under stress or illness.