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Related Experiment Videos

Selenium and rubidium changes in subjects with pathologically altered thyroid.

J Kvícala1, J Havelka, J Nĕmec

  • 1Institute of Endocrinology, Praha, CSFR.

Biological Trace Element Research
|January 1, 1992
PubMed
Summary
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Selenium (Se) and rubidium (Rb) levels were analyzed in thyroid conditions. Selenium decreased, while rubidium increased, in pathological thyroids, suggesting potential diagnostic uses for Rb.

Area of Science:

  • Endocrinology
  • Oncology
  • Nuclear Chemistry

Background:

  • Thyroid diseases, including hyperthyroidism, carcinomas, and adenomas, can alter cellular metabolism.
  • Selenium (Se) is known for its protective effects in thyroid cells and against carcinogenicity.
  • The role of rubidium (Rb) in thyroid cell function and pathology is largely unexplored.

Purpose of the Study:

  • To investigate the concentrations of selenium and rubidium in patients with various thyroid pathologies compared to healthy controls.
  • To explore the potential diagnostic utility of altered elemental concentrations in pathological thyroid tissues.

Main Methods:

  • Neutron activation analysis was employed to quantify selenium and rubidium concentrations.
  • Measurements were performed on tissue samples from subjects with hyperthyroidism, carcinomas, adenomas, and control groups.

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  • Coirradiated inorganic standards and International Atomic Energy Agency (IAEA) reference material were used for calibration and quality control.

    • Main Results:

    • Selenium concentrations were found to be decreased in all pathological thyroid groups.
    • Rubidium concentrations were elevated in all pathological thyroid groups.
    • The most significant alterations in both selenium (decrease) and rubidium (increase) were observed in thyroids affected by carcinomas.

    Conclusions:

    • Altered levels of selenium and rubidium correlate with thyroid pathologies, particularly thyroid cancer.
    • The observed increase in rubidium in pathological thyroids may offer a novel diagnostic marker.
    • Further research into the specific mechanisms of rubidium in thyroid cells is warranted.