[Drugs and drug combinations responsible for cutaneomucosal reactions]

The drugs and drug combinations responsible for cutaneo-mucosal reactions are very numerous, which explains why this undesireable side effect is the most frequent of all. Multiple pathogenic mechanisms are described: immunoallergic with its different types of reactions, overdosage, idiosyncrasy, drug interactions, etc. The reactions of produced vary from the maculo-papular rash to definitive staining of the skin. A few specific cases have been analyzed: the allergic reactions with penicillins, the photo-toxicity of certain tetracyclines, licheniform eruptions with gold salts or lupus erythematosus with penicillamine. Centralization of pharmacological information is desireable in order to better understand these reactions.