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Updated: Aug 13, 2026

Effects of Allogeneic Platelet-Rich Plasma (PRP) on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
Published on: March 19, 2018
Experimental substantiation of allogenic tendon tissue transplantation
V A Plotnikova1, I A Stakheyev, V P Shtin
1Sverdlovsk Branch, All-Union Kurgan Scientific Centre for Reconstructive Traumatology and Orthopedics, Ministry of Health, Yekaterinoburg, Russia.
Abstract:
Substantiation of transplantation of tendon allografts treated with a new solution showing both sterilizing and preservatory effects was provided in experiments on 84 dogs. The solution prepared on the basis of 0.1% formaldehyde with the addition of dimethyl sulphoxide, monomycin and prednisolone (FDMP) shows a high antimicrobial activity, preserves the structure of the tendons and their elasticity. In their duration, the processes of reconstruction of allografts preserved in FDMP are very similar to autotransplants. Clinical application of preserved tendons on repairing defects in 418 patients proved the method to be highly effective.

