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Related Experiment Videos

Monoamine metabolism in human brain.

D S Robinson, T L Sourkes, A Nies

    Archives of General Psychiatry
    |January 1, 1977
    PubMed
    Summary

    Human brain enzyme activity, including monoamine oxidase (MAO), changes with age and sex. MAO activity increases with age and is higher in females, impacting central nervous system amine metabolism.

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    Area of Science:

    • Neuroscience
    • Biochemistry
    • Human Physiology

    Background:

    • Amine metabolism is crucial for central nervous system function.
    • Factors like age and sex may influence neurotransmitter levels and enzyme activity.

    Purpose of the Study:

    • To investigate the relationship between age, sex, and the levels of key enzymes involved in catecholamine metabolism in various human brain regions.
    • To analyze the activity of monoamine oxidase (MAO), catechol-O-methyltransferase (COMT), and tyrosine hydroxylase (TH).

    Main Methods:

    • Autopsy human brain tissue from 39 individuals was analyzed.
    • Levels of norepinephrine (NE), dopamine (DA), TH, COMT, and MAO were measured.
    • Nine distinct brain areas were examined: globus pallidus, thalamus, hypothalamus, hippocampus, substantia nigra, floor of the fourth ventricle, orbital cortex, caudate nucleus, and mammillary bodies.

    Main Results:

    • Monoamine oxidase (MAO) activity showed a positive correlation with age across all studied brain areas.
    • Mean MAO activity was significantly higher in female subjects compared to males.
    • Increased MAO activity was observed during late childhood and adolescence.

    Conclusions:

    • Age and sex are significant determinants of amine metabolism in the human brain.
    • Findings support the role of MAO in age- and sex-related changes in central nervous system amine metabolism.

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