Related Experiment Video
Updated: Jul 25, 2026

Particle Agglutination Method for Poliovirus Identification
Published on: April 20, 2011
Molecular basis of antigenic structures of poliovirus: implications for their evolution during morphogenesis
1Heinrich-Pette-Institut für Experimentelle Virologie Universität Hamburg, Germany.
Abstract:
Neutralizing monoclonal antibodies against poliovirus type 1 were obtained after conventional immunization or combined in vivo-in vitro immunization. Antibody binding sites were determined by sequence analysis of neutralization-resistant mutants. Site 3 variants had several amino acid substitutions in previously unidentified positions for neutralization resistance. Evidence for a linkage of subsites 3a and 3b is presented. Some site 3b antibodies as defined previously precipitated 14S subunits, although with reduced titers.
More Related Videos
Related Concept Videos
Viral Structure
Viral Mutations
Leaky Scanning
Size and Structure of Viral Genomes
Poliomyelitis
Inhibitors of Virion Maturation and Assembly

