Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antimutagenicity in yeast.

G Bronzetti1, C Della Croce, A Galli

  • 1Istituto di Mutagenesi e Differenziamento, CNR, Pisa, Italy.

Mutation Research
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct Samples of Interstellar and Interplanetary Material with IMAP.

Space science reviews·2026
Same author

Does maternal respiration modulate maternal-fetal cardiovascular coupling?

Computers in biology and medicine·2026
Same author

Interstellar Mapping And Acceleration Probe: The NASA IMAP Mission.

Space science reviews·2025
Same author

Vortioxetine Treatment for Depression in Patients with Prodromal vs Mild Alzheimer's Disease: A Six-Month, Open-Label, Observational Study.

The journal of prevention of Alzheimer's disease·2024
Same author

Objective interpretation of ultraviolet-induced luminescence for characterizing pictorial materials.

Scientific reports·2023
Same author

Future Exploration of the Outer Heliosphere and Very Local Interstellar Medium by Interstellar Probe.

Space science reviews·2023
Same journal

Monoallelic germline RAD51C, RAD51D, and BRIP1 variants in hereditary cancer testing: Variant spectrum and clinical counselling implications.

Mutation research·2026
Same journal

Prediction of hepatocellular carcinoma associated biomarkers in TP53 gene; A comprehensive in silico analysis.

Mutation research·2026
Same journal

IDH1 mutation promotes angiogenesis via upregulation of hypoxia inducible factor 1 alpha in glial tumors.

Mutation research·2026
Same journal

Targeting overexpressed oncogenes in esophageal cancer through miRNA-mediated gene silencing: Insights from binding affinity and thermodynamic profiling.

Mutation research·2026
Same journal

The active compound quercetin from Polygonum cuspidatum targets COL3A1 to enhance CD8⁺ T cell cytotoxicity in gastric cancer.

Mutation research·2026
Same journal

E2F1 promotes LIHC malignant phenotype via NEK2-mediated Wnt/β-catenin and Notch activation and EMT.

Mutation research·2026
See all related articles

Antimutagenesis research explores compounds that prevent DNA mutations. Studies in eukaryotic systems, particularly yeast, have identified various agents like caffeine, L-methionine, and fermented milk exhibiting antimutagenic properties.

Area of Science:

  • Microbiology
  • Genetics
  • Biochemistry

Background:

  • Growing interest in antimutagenesis across prokaryotic and eukaryotic systems.
  • Early eukaryotic studies focused on Schizosaccharomyces pombe, investigating compounds like caffeine and L-methionine.
  • Subsequent research utilized Saccharomyces cerevisiae strains to assess a broad spectrum of compounds.

Purpose of the Study:

  • To review and highlight key findings in eukaryotic antimutagenesis research.
  • To identify specific compounds and agents demonstrating antimutagenic activity.
  • To provide an overview of methods and results in yeast-based antimutagenesis studies.

Main Methods:

  • Utilized various strains of Schizosaccharomyces pombe for initial investigations.
  • Employed different strains of Saccharomyces cerevisiae, including the widely used Strain D7.

Related Experiment Videos

  • Tested a diverse range of compounds, including acridine, saccharin, salts, tumor promoters, co-carcinogens, spermine, chlorophyllin, cobaltous chloride, and fermented milk.

    • Main Results:

    • Caffeine and L-methionine showed antimutagenic effects in Schizosaccharomyces pombe.
    • Studies with Saccharomyces cerevisiae reported antimutagenic activity for compounds such as spermine, chlorophyllin, cobaltous chloride, and fermented milk.
    • A wide array of chemical agents and natural products were evaluated for their potential to inhibit mutagenesis.

    Conclusions:

    • Eukaryotic yeast systems, particularly Saccharomyces cerevisiae, are valuable models for studying antimutagenesis.
    • Several compounds, both synthetic and naturally derived, possess significant antimutagenic potential.
    • Further research into these agents could lead to strategies for preventing genetic damage.