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Antimutagenic effects in humans.
1Biomedical Sciences Division, University of California, Lawrence Livermore National Laboratory 94550.
Mutation Research
|June 1, 1992
Summary
Antimutagenicity studies can now assess human somatic mutation using established assays. Future research should explore interventions targeting newly formed mutations to reduce cancer risk.
Area of Science:
- Human toxicology
- Somatic mutation research
- Antimutagenesis
Background:
- Human somatic mutation can be measured in lymphocytes and erythrocytes using five assay-gene combinations.
- Established methods define background mutation levels and mutagenic responses.
Purpose of the Study:
- To discuss the application of antimutagenicity studies to human somatic mutation.
- To highlight the potential for future research in this area.
Main Methods:
- Utilizing five assay-gene combinations for measuring human somatic mutation.
- Defining human background mutation levels and responses to mutagens.
Main Results:
- Established background levels for human somatic mutation.
- Demonstrated clear responses of mutant frequency to various mutagens.
Conclusions:
- Antimutagenicity testing on background mutation frequencies is feasible but not yet performed.
- A key challenge is the unknown age of mutant cells, as only newly formed mutants are susceptible to antimutagenic treatments.
- Future studies should consider intervention strategies for active mutagenicity and other genotoxicity endpoints.