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Human platelets deficient in dense granules contain normal amounts of pp60c-src
A Sorisky1, B Lages, H J Weiss
1Department of Biochemistry, University of Vermont College of Medicine, Burlington 05405.
Thrombosis Research
|January 1, 1992
Abstract:
We have determined that pp60c-src, a protein tyrosine kinase abundant in normal platelets, is present at comparable levels in platelets that are deficient in dense granules (Hermansky-Pudlak syndrome). Relative quantitation of pp60c-src was performed by immunoblot analysis after protein separation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Our data suggest that human platelet dense granules, unlike chromaffin cell secretory granules, are not the major intracellular site of localization of pp60c-src.