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Demonstration of mismatch negativity in the monkey
D C Javitt1, C E Schroeder, M Steinschneider
1Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY 10461.
Abstract:
In humans, deviant auditory stimuli elicit an event-related potential (ERP) component, termed "mismatch negativity" (MMN), that reflects the operation of a cortical detector of infrequent stimulus change. Epidural auditory ERPs were recorded from 3 cynomolgous monkeys in response to soft and loud clicks. "Oddball" loud or soft stimuli elicited a long-duration frontocentral negativity, peaking at approximately 85 msec, that was superimposed upon cortically generated obligatory ERP components. These data suggest that monkeys might serve as a heuristically valuable system in which to study the neurochemical and neuroanatomical substrates of early context-dependent ERP generation.
Insights
Monkeys exhibit mismatch negativity (MMN), an auditory event-related potential (ERP) reflecting change detection. This study in monkeys suggests they are a valuable model for understanding the neural basis of early context-dependent ERPs.
Area of Science:
- Neuroscience
- Auditory Neuroscience
- Cognitive Neuroscience
Background:
- Deviant auditory stimuli in humans elicit mismatch negativity (MMN).
- MMN is an event-related potential (ERP) reflecting cortical change detection.
- Understanding MMN's neural basis is crucial for cognitive neuroscience.
Purpose of the Study:
- To investigate the presence of MMN in non-human primates.
- To explore the potential of using monkeys as a model system for studying MMN.
- To examine the neurochemical and neuroanatomical substrates of early context-dependent ERPs.
Main Methods:
- Epidural auditory event-related potentials (ERPs) were recorded from three cynomolgous monkeys.
- Monkeys were exposed to sequences of soft and loud auditory clicks.
- "Oddball" stimuli (infrequent loud or soft clicks) were presented to elicit MMN.
Main Results:
- A long-duration frontocentral negativity was observed in response to "oddball" stimuli.
- This negativity peaked around 85 milliseconds post-stimulus.
- The observed negativity was superimposed on obligatory ERP components.
Conclusions:
- Monkeys exhibit an MMN-like response to deviant auditory stimuli.
- These findings suggest monkeys are a valuable model for studying the neurobiology of MMN.
- Further research in monkeys can elucidate the neurochemical and neuroanatomical underpinnings of early context-dependent ERPs.