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Cytogenetic abnormalities in renal oncocytic neoplasms
S M Dobin1, C P Harris, J A Reynolds
1Department of Pathology, Scott and White Hospital, Scott, Sherwood and Brindley Foundation, Texas A&M University College of Medicine, Temple 76508.
Genes, Chromosomes & Cancer
|January 1, 1992
Summary
Cytogenetic studies on renal oncocytomas reveal frequent numerical and structural abnormalities. Trisomy 12 and sex chromosome loss are common findings in these kidney tumors.
Area of Science:
- Nephrology
- Cytogenetics
- Oncology
Background:
- Renal oncocytomas are benign kidney tumors requiring accurate diagnosis.
- Cytogenetic analysis provides insights into the molecular basis of tumor development.
Observation:
- Five renal oncocytomas (3 grade 2, 2 grade 1) underwent cytogenetic study.
- Four tumors displayed both normal and abnormal cell lines.
- Mitotic cells were absent in one grade 1 tumor.
Findings:
- Numerical chromosomal abnormalities were present in one grade 1 and two grade 2 tumors.
- Structural abnormalities were exclusively observed in grade 2 tumors.
- Aneuploidy of chromosome 12 was detected in both grade 1 and grade 2 tumors, with grade 2 exhibiting more extensive changes.
- Loss of a sex chromosome, abnormalities of chromosomes 1 and 22, and trisomy 12 were the most frequent cytogenetic alterations.
Implications:
- Cytogenetic findings can aid in the differential diagnosis of renal oncocytomas.
- Understanding chromosomal aberrations may elucidate the pathogenesis of renal oncocytoma.
- Absence of chromosome 3 abnormalities distinguishes renal oncocytomas from renal cell carcinoma.