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Chromosome aberrations in an alpha-fetoprotein-producing hepatoblastoma
G Annerén1, H Nordlinder, F Hedborg
1Department of Clinical Genetics, University Hospital, Uppsala, Sweden.
Genes, Chromosomes & Cancer
|January 1, 1992
Abstract:
The cytogenetic findings of an alpha-fetoprotein (AFP)-producing hepatoblastoma in a 14-month-old girl are reported. Ten of 36 tumor cells were chromosomally abnormal, yielding the composite karyotype 47,XX,2q +, t(3;5)(p25;q31),dup(4)(q12q26), +20. Three of the chromosomal abnormalities (2q+, break at 4q12, +20) have been reported previously and might be of pathogenetic significance.