Related Experiment Video
Updated: Aug 6, 2026

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
Published on: March 22, 2017
Oesophageal replacement in paediatric patients
1Cardiothoracic Unit, University of Nigeria Teaching Hospital, Enugu.
Insights
Pediatric patients with undilatable esophageal strictures tolerated esophageal replacement using colonic conduits well. This surgical approach demonstrated good short- and medium-term outcomes for children with corrosive esophageal burns.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Thoracic Surgery
Background:
- Undilatable esophageal strictures in children often result from accidental corrosive burns.
- Esophageal replacement is a complex procedure in pediatric patients.
Purpose of the Study:
- To evaluate the safety and efficacy of isoperistaltic colonic conduit for esophageal replacement in children with undilatable strictures.
- To assess short- and medium-term outcomes and complications associated with this procedure.
Main Methods:
- A cohort of 24 children (aged 16 months to 12 years) underwent esophageal replacement with an isoperistaltic colonic conduit between January 1986 and December 1990.
- All strictures were secondary to accidental corrosive ingestion.
- Patients were monitored for postoperative complications and functional outcomes, including swallowing ability.
Main Results:
- The procedure was well-tolerated, with all patients achieving the ability to swallow within 3 weeks post-surgery.
- No operative or postoperative deaths occurred.
- Major complications included pneumothorax (2 cases), Ascaris lumbricoides-induced gastric outlet obstruction (2 cases), and cervical fistulas (8 cases) that resolved spontaneously.
Conclusions:
- Esophageal replacement with isoperistaltic colonic conduit is a viable and well-tolerated option for children with undilatable esophageal strictures.
- The procedure offers good short- and medium-term results, though long-term concerns regarding the native esophagus remain.
- This technique provides a safe alternative for managing severe esophageal damage in pediatric populations.
Abstract:
Over a 5-year period from January 1986 to December 1990, 24 children aged between 16 months and 12 years with undilatable oesophageal stricture had oesophageal replacement with isoperistaltic colonic conduit. All the strictures followed accidental corrosive burns. The procedure was well tolerated; all the patients were able to swallow within 3 weeks of surgery. Major postoperative complications were threatening pneumothorax (two cases), gastric outlet obstruction due to Ascaris lumbricoides (two cases) and cervical fistula (eight cases) which closed spontaneously in each case. There were no operative or postoperative deaths. Twenty-two patients have been followed up for 2-59 months. Children tolerate oesophageal replacement well. The short-term and medium-term results are good, but anxiety over the fate of the retained native oesophagus is noted.
Related Concept Videos
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Enteral Nutrition I: Orogastric and Nasogastric Feeding
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...

