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Effect of myocardial infarction on components of fibrinolytic system

E Gidron, R Margalit, A Oliven

    British Heart Journal
    |January 1, 1977
    PubMed

    Insights

    Following acute myocardial infarction, fibrinolytic activity is reduced, with levels returning to normal within 15 months. This study investigated changes in the fibrinolytic system after heart attack.

    Area of Science:

    • Cardiology
    • Hematology
    • Thrombosis Research

    Background:

    • The fibrinolytic system is crucial for dissolving blood clots.
    • Acute myocardial infarction (heart attack) can impact hemostasis and fibrinolysis.
    • Understanding post-myocardial infarction changes in fibrinolysis is important for patient outcomes.

    Purpose of the Study:

    • To systematically investigate the fibrinolytic system's behavior after acute myocardial infarction.
    • To assess the duration and pattern of changes in fibrinolytic activity and related factors.

    Main Methods:

    • Systematic investigation of 42 patients post-acute myocardial infarction.
    • Measurement of fibrinolytic activity, fibrinogen, plasminogen, and antiplasmin levels.
    • Follow-up re-examination of 24 patients after 12-15 months.

    Main Results:

    • Progressive reduction in fibrinolytic activity observed, peaking around days 4-5 post-infarction.
    • Concomitant increase in fibrinogen, plasminogen, and antiplasmin levels.
    • Antiplasmin levels correlated with delayed lysis; normal levels and lysis times restored in re-examined patients.

    Conclusions:

    • Reduced fibrinolytic activity after acute myocardial infarction is a transient phenomenon.
    • The fibrinolytic system generally recovers to normal levels within 12-15 months post-event.

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