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Banked blood microfiltration. II. Dacron-wool microfilter
Abstract:
It is well established that debris tends to accumulate in banked blood, the amount of debris increasing with storage time. If such a blood is transfused to a patient, it will be filtered by the capillary network of the lungs and could cause various intensities of microemboli. These can be prevented by microfiltration--the Swank IL200 transfusion filter made of Dacron wool is perfectly suitable. It removes more than 70% of the debris 29-100 mum size from four blood units and its efficiency for particle removal is greatly increased by lactate priming.
Insights
Blood storage causes debris accumulation, potentially leading to lung microemboli. Microfiltration using the Swank IL200 filter effectively removes over 70% of debris, with lactate priming enhancing efficiency.
Area of Science:
- Transfusion Medicine
- Biomaterials Science
Background:
- Accumulation of particulate debris in banked blood increases with storage duration.
- Transfusion of stored blood can lead to pulmonary microembolism due to filtered debris in the lung capillaries.
Purpose of the Study:
- To evaluate the efficacy of the Swank IL200 transfusion filter for removing particulate debris from banked blood.
- To assess the impact of lactate priming on the debris removal efficiency of the filter.
Main Methods:
- Utilized the Swank IL200 filter, composed of Dacron wool, for microfiltration of banked blood units.
- Quantified debris removal efficiency for particles in the 29-100 micrometer size range.
- Investigated the effect of lactate priming on filter performance.
Main Results:
- The Swank IL200 filter removed over 70% of debris (29-100 µm) from four units of banked blood.
- Lactate priming significantly enhanced the particle removal efficiency of the filter.
Conclusions:
- Microfiltration with the Swank IL200 filter is an effective method to prevent microemboli caused by blood debris.
- Lactate priming offers a strategy to improve the performance of transfusion filters for banked blood.