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Cellular adaptation to morphine in rats.

A E TAKEMORI

    Science (New York, N.Y.)
    |March 31, 1961
    PubMed
    Summary

    Morphine depresses brain cell respiration in control rats but not in rats with chronic morphine exposure. This shows cellular adaptation to morphine mirrors whole-animal tolerance.

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    Area of Science:

    • Neuropharmacology
    • Cellular Biology
    • Physiology

    Background:

    • Morphine is a potent opioid analgesic with known effects on the central nervous system.
    • Chronic morphine administration leads to the development of tolerance and physical dependence in animals and humans.

    Purpose of the Study:

    • To investigate the effects of morphine on brain cell respiration in rats.
    • To determine if cellular adaptation to morphine occurs at the level of brain tissue respiration.

    Main Methods:

    • Utilized KCl-stimulated cortical slices of brain from control and chronically morphine-treated rats.
    • Measured the rate of cellular respiration in these brain slices.

    Main Results:

    • Morphine significantly depressed the respiration of cortical slices from control rats.
    • The respiration of cortical slices from rats chronically exposed to morphine was unaffected by the drug.

    Conclusions:

    • Demonstrates a cellular-level adaptation to morphine in rat brain tissue.
    • This cellular adaptation is concurrent with the whole-animal adaptation (tolerance) to morphine.
    Keywords:
    CEREBRAL CORTEX/pharmacologyMORPHINE/pharmacology

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