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Tumor angiogenesis: evidence of new blood channels from plasma infiltrations
I Freitas1, G F Baronzio, S Barni
1Department of Animal Biology, University of Pavia, Italy.
EXS
|January 1, 1992
Abstract:
Stroma formation in Ehrlich carcinoma, studied with histochemical and TEM techniques, is similar to wound healing. In this tumour mast cells, macrophages, adipocytes, platelets and fibrin seem to co-operate locally with malignant cells in regulating stroma formation. The gaps opened in the tumor parenchyma by plasma outpouring from local blood vessels seem to offer easy routes for endothelial cell migration towards ill-nourished areas, and may explain the irregular aspect of tumor microvascularity.