Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrical field effects on crushed nerve regeneration.

J M Kerns1, C Lucchinetti

  • 1Department of Anatomy, Rush Presbyterian St. Luke's Medical Center, Chicago, Illinois 60612.

Experimental Neurology
|July 1, 1992
PubMed
Summary

Electrical fields show minor benefits for crushed sciatic nerve regeneration in rats. While motor recovery was similar, treated nerves appeared healthier and had improved nerve structure, suggesting potential for enhanced nerve repair.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of fibrin glue, bioresorbable tubing and sutures in peripheral nerve repair.

Restorative neurology and neuroscience·2011
Same author

Electrical stimulation of nerve regeneration in the rat: functional evaluation by a twitch tension method.

Restorative neurology and neuroscience·2011
Same author

Pathological heterogeneity of idiopathic central nervous system inflammatory demyelinating disorders.

Current topics in microbiology and immunology·2008
Same author

Increased duration of simulated childbirth injuries results in increased time to recovery.

American journal of physiology. Regulatory, integrative and comparative physiology·2007
Same author

Pattern of T2 hypointensity associated with ring-enhancing brain lesions can help to differentiate pathology.

Neuroradiology·2006
Same author

Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions.

Archives of neurology·2005

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Biomedical Engineering

Background:

  • Electrical stimulation has shown promise in enhancing nerve regeneration after injury.
  • Understanding the specific effects of electrical fields on peripheral nerve repair is crucial for developing new therapeutic strategies.

Purpose of the Study:

  • To investigate the impact of a continuous electrical field on the regeneration of crushed rat sciatic nerves.
  • To compare functional, histological, and morphometric recovery between electrically stimulated and untreated nerves.

Main Methods:

  • A 10 microA electrical field was applied to the transected sciatic nerve in rats, with the cathode at the distal stump.
  • Locomotion behavior (sciatic functional index) and motor recovery (twitch tension) were assessed.

Related Experiment Videos

  • Histological and morphometric analyses were performed 28 days post-operation.
  • HRP-labeled motoneurons and endoneurial space were examined.

    • Main Results:

    • Locomotion recovery and twitch tension were similar between the treated and untreated groups.
    • A transient enhancement in motor recovery occurred 2-4 days earlier in the treated group.
    • Histology indicated healthier nerve appearance in the treated group.
    • Morphometry revealed improved nerve area, fiber density, and number in the treated group compared to untreated.
    • The enlarged endoneurial space was reduced in the treated group.

    Conclusions:

    • Electrical fields demonstrated a small, positive effect on specific aspects of sciatic nerve regeneration after crush injury.
    • While not significantly improving overall functional recovery, electrical fields may promote healthier nerve structure and earlier functional improvements.
    • Further research is warranted to optimize electrical field parameters for enhanced peripheral nerve repair.