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Granulocyte colony stimulating factor in the management of chronic neutropenia
P V Marlton1, S J Wright, K M Taylor
1Department of Haematology, Mater Misericordiae Hospitals, South Brisbane, QLD.
The Medical Journal of Australia
|May 18, 1992
Abstract
Objective:
To report two cases of chronic neutropenic states successfully treated with granulocyte colony stimulating factor (G-CSF).
Clinical Features:
A 23-year-old man with severe congenital cyclic neutropenia causing lifelong recurrent infections and consequent debilitation presented with intractable infected leg ulcers. A 56-year-old man with acquired idiopathic neutropenia presented with severe perianal infection and sepsis.
Intervention And Outcome:
Both patients were successfully treated with recombinant G-CSF.
Conclusion:
G-CSF is an agent with major clinical potential for the therapy of primary neutropenic states.