Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heart rate dynamics after acute cocaine administration.

A Garfinkel1, S L Raetz, R M Harper

  • 1Brain Research Institute, UCLA School of Medicine 90024-1761.

Journal of Cardiovascular Pharmacology
|March 1, 1992
PubMed
Summary

High-dose cocaine administration in cats significantly reduced heart rate variability, even after heart rate returned to normal. This indicates cocaine disrupts cardiac autonomic control, restricting rate fluctuations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impaired hypercarbic and hypoxic responses from developmental loss of cerebellar Purkinje neurons: implications for sudden infant death syndrome.

Cerebellum (London, England)·2014
Same author

Food-intake dysregulation in type 2 diabetic Goto-Kakizaki rats: hypothesized role of dysfunctional brainstem thyrotropin-releasing hormone and impaired vagal output.

Neuroscience·2013
Same author

Generation of finite wave trains in excitable media.

Europhysics letters·2011
Same author

Selectively diminished corpus callosum fibers in congenital central hypoventilation syndrome.

Neuroscience·2011
Same author

Chaos control of cardiac arrhythmias.

Trends in cardiovascular medicine·2011
Same author

CEREBRAL ANEURYSM WITH RECURRENT LEAKAGE.

British medical journal·2010

Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Research
  • Pharmacology

Background:

  • Cocaine is known to affect cardiovascular function.
  • Understanding the detailed impact of cocaine on heart rate variability (HRV) is crucial for assessing its physiological risks.

Purpose of the Study:

  • To investigate the effects of a high intravenous dose of cocaine on heart rate patterns and variability in unrestrained cats.

Main Methods:

  • Bolus intravenous administration of a high dose (10 mg/kg) of cocaine.
  • Assessment of heart rate (HR) and R-R intervals using measures of variability and nonlinear methods.
  • Evaluation across three periods: waking baseline, early post-cocaine, and recovery.

Main Results:

Related Experiment Videos

  • Cocaine induced initial tachycardia and a significant reduction in heart rate variability.
  • Reduced variability persisted even when average heart rate returned to baseline levels during the recovery period.
  • Nonlinear analysis revealed increased beat-to-beat correlation and a tendency for immediate alternations between acceleration and deceleration.

Conclusions:

  • High-dose cocaine administration disrupts cardiac autonomic regulation, leading to sustained reduction in heart rate variability.
  • The drug imposes a constrained cardiac rhythm, limiting natural fluctuations.
  • These findings highlight cocaine's profound impact on cardiovascular control mechanisms.