Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Capillary growth: a two-cell system.

P A D'Amore1

  • 1Department of Surgery, Children's Hospital, Boston, MA 02115.

Seminars in Cancer Biology
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Pericytes, a second cell type in capillaries, interact with endothelial cells (EC) to control microvascular growth. Understanding these interactions is key to studying angiogenesis in health and disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TGF-β signaling is required for maintenance of retinal ganglion cell differentiation and survival.

Neuroscience·2011
Same author

Is blockade of vascular endothelial growth factor beneficial for all types of diabetic retinopathy?

Diabetologia·2008
Same author

What tangled webs they weave: Rho-GTPase control of angiogenesis.

Cellular and molecular life sciences : CMLS·2007
Same author

Development of the endothelium.

Handbook of experimental pharmacology·2006
Same author

Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival.

Developmental biology·2003
Same author

Wnt signaling in the vasculature.

Angiogenesis·2003
Same journal

Role of oral microbiome in cancer immunotherapy.

Seminars in cancer biology·2026
Same journal

Unveiling tumor heterogeneity by single cell RNA-sequencing: From basic considerations to clinical applications.

Seminars in cancer biology·2026
Same journal

Hidden architecture of resistance: The extracellular matrix in melanoma's immune landscape.

Seminars in cancer biology·2026
Same journal

Microfluidic technologies for extracellular vesicle isolation and analysis: Implications for translational applications in cancer therapy.

Seminars in cancer biology·2026
Same journal

Exploring glioblastoma microenvironment using organoids: opportunities, limitations, and emerging concepts.

Seminars in cancer biology·2026
Same journal

Special issue: Lipid metabolic alterations in cancer: Pathogenic mechanisms, therapies and common pathophysiology with cardiovascular disease.

Seminars in cancer biology·2026
See all related articles

Area of Science:

  • Cell Biology
  • Vascular Biology
  • Biomedical Research

Background:

  • Angiogenesis, or new blood vessel growth, is crucial in both normal physiological processes and pathological conditions like tumor development.
  • Endothelial cells (EC) have been the primary focus of microvascular growth studies, yet capillaries also contain pericytes, a second cell type with largely unknown functions.
  • Pericytes, historically defined by their position, are now recognized as potentially playing roles in contraction, stem cell functions, and microvascular growth regulation.

Purpose of the Study:

  • To investigate the role of pericytes in microvascular growth and their interactions with endothelial cells (EC).
  • To explore the influence of pericytes on EC growth and function during later stages of vessel development.

Main Methods:

  • Isolation, culture, and identification of pericytes.

Related Experiment Videos

  • In vivo observation of EC and pericyte contact.
  • Co-culture studies examining EC-pericyte interactions, including diffusible growth regulators, heterotypic contacts, and gap junctions.

    • Main Results:

    • EC and pericytes engage in frequent contact in vivo.
    • Co-culture studies demonstrate multifaceted interactions between EC and pericytes.
    • Identified interaction mechanisms include diffusible growth regulators, heterotypic contacts, and gap junctions.

    Conclusions:

    • Pericytes are an integral component of capillaries, not just endothelial cells.
    • Intercellular communication between EC and pericytes is vital for controlling microvascular growth and function.
    • Further research into pericyte-EC interactions can advance understanding of angiogenesis in various biological contexts.