Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mast cells and angiogenesis.

C J Meininger1, B R Zetter

  • 1Department of Medical Physiology, Microcirculation Research Institute, Texas A&M University Health Science Center, College Station 77843-1114.

Seminars in Cancer Biology
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A role for collagen XXIII in cancer cell adhesion, anchorage-independence and metastasis.

Oncogene·2011
Same author

miR-135a contributes to paclitaxel resistance in tumor cells both in vitro and in vivo.

Oncogene·2011
Same author

Antizyme, a mediator of ubiquitin-independent proteasomal degradation and its inhibitor localize to centrosomes and modulate centriole amplification.

Oncogene·2007
Same author

Vacuolar-type H+-ATPases at the plasma membrane regulate pH and cell migration in microvascular endothelial cells.

American journal of physiology. Heart and circulatory physiology·2006
Same author

The metabolic basis of arginine nutrition and pharmacotherapy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2002
Same author

Tetrahydrobiopterin levels regulate endothelial cell proliferation.

American journal of physiology. Heart and circulatory physiology·2001
Same journal

Role of oral microbiome in cancer immunotherapy.

Seminars in cancer biology·2026
Same journal

Unveiling tumor heterogeneity by single cell RNA-sequencing: From basic considerations to clinical applications.

Seminars in cancer biology·2026
Same journal

Hidden architecture of resistance: The extracellular matrix in melanoma's immune landscape.

Seminars in cancer biology·2026
Same journal

Microfluidic technologies for extracellular vesicle isolation and analysis: Implications for translational applications in cancer therapy.

Seminars in cancer biology·2026
Same journal

Exploring glioblastoma microenvironment using organoids: opportunities, limitations, and emerging concepts.

Seminars in cancer biology·2026
Same journal

Special issue: Lipid metabolic alterations in cancer: Pathogenic mechanisms, therapies and common pathophysiology with cardiovascular disease.

Seminars in cancer biology·2026
See all related articles

Mast cells are linked to blood vessel growth (angiogenesis) in both normal and diseased states. Understanding mast cell roles in angiogenesis could lead to new ways to control blood vessel formation.

Area of Science:

  • Immunology
  • Vascular Biology
  • Cell Biology

Background:

  • A correlation between mast cell accumulation and angiogenesis is well-documented in scientific literature.
  • This association applies to both physiological and pathological blood vessel development.
  • The precise mechanisms of mast cell recruitment to angiogenic sites require further elucidation.

Purpose of the Study:

  • To explore the multifaceted role of mast cells in the process of angiogenesis.
  • To investigate how mast cell products influence endothelial cell behavior and extracellular matrix remodeling during neovascularization.

Main Methods:

  • Literature review and synthesis of existing data on mast cells and angiogenesis.
  • Analysis of proposed mechanisms for mast cell involvement in endothelial cell migration, proliferation, and matrix degradation.

Related Experiment Videos

Main Results:

  • Mast cells contribute to angiogenesis through direct effects on endothelial cells (migration, proliferation).
  • Mast cells indirectly promote neovascularization by degrading connective tissue, facilitating sprout formation.
  • The recruitment of mast cells to angiogenic sites remains an area needing further research.

Conclusions:

  • Mast cells play a significant role in both normal and pathological angiogenesis.
  • Targeting mast cell functions presents potential therapeutic strategies for modulating neovascularization.
  • Further research into mast cell recruitment and function is crucial for developing interventions.