Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparative efficacy of antidepressants.

S Kasper1, J Fuger, H J Möller

  • 1Psychiatric Department, University of Bonn, Germany.

Drugs
|January 1, 1992
PubMed
Summary

Selective serotonin reuptake inhibitors (SSRIs) show antidepressant efficacy comparable to tricyclic antidepressants. While generally well-tolerated, SSRIs may cause nausea, especially at higher initial doses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Non-Response to Antidepressants: Risk Factors and Therapeutic Possibilities.

Pharmacopsychiatry·2026
Same author

Vagal Nerve Stimulation-Modulation of the Anti-Inflammatory Response and Clinical Outcome in Psoriatic Arthritis or Ankylosing Spondylitis.

Mediators of inflammation·2021
Same author

The role of interleukin-18 in the diagnosis and monitoring of hemophagocytic lymphohistiocytosis/macrophage activation syndrome - a systematic review.

Clinical and experimental immunology·2020
Same author

Short-term transcutaneous non-invasive vagus nerve stimulation may reduce disease activity and pro-inflammatory cytokines in rheumatoid arthritis: results of a pilot study.

Scandinavian journal of rheumatology·2020
Same author

Soluble CD163 and soluble mannose receptor predict survival and decompensation in patients with liver cirrhosis, and correlate with gut permeability and bacterial translocation.

Alimentary pharmacology & therapeutics·2017
Same author

Letter: autoimmune hepatitis-drug-induced liver injury must always be excluded. Authors' reply.

Alimentary pharmacology & therapeutics·2017

Area of Science:

  • Pharmacology
  • Psychiatry

Background:

  • Selective serotonin reuptake inhibitors (SSRIs) represent a newer class of antidepressants.
  • SSRIs demonstrate significant antidepressant efficacy compared to placebo.

Purpose of the Study:

  • To compare the efficacy of SSRIs with standard tricyclic antidepressants.
  • To review the clinical characteristics and tolerability profiles of SSRIs.

Main Methods:

  • Meta-analysis of controlled trials comparing SSRIs with tricyclic antidepressants.
  • Review of clinical trial data regarding SSRI efficacy, pharmacokinetics, and adverse effects.

Main Results:

  • SSRIs exhibit antidepressant efficacy similar to tricyclic antidepressants like amitriptyline and imipramine.
  • Differences in elimination half-life exist among SSRIs, impacting drug interactions.
  • SSRIs generally have a more favorable tolerability profile than tricyclics, with fewer anticholinergic effects, sedation, cardiotoxicity, or weight gain.

Conclusions:

  • SSRIs are effective antidepressants with a generally favorable tolerability profile compared to tricyclic antidepressants.
  • Further research is needed to definitively establish the relative efficacy of specific SSRIs.
  • SSRIs show promise in treating various psychiatric disorders beyond depression, including panic disorder, OCD, and eating disorders.

Related Experiment Videos