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Affinity chromatography of serine proteinases from the bovine intervertebral disc on BPTI-Separon HEMA 1000

J Stovícková1, V Podrazký, K Trnavský

  • 1Institute of Rheumatic Diseases, Prague, Czechoslovakia.

A method for the purification of serine proteinases from the bovine intervertebral disc using affinity chromatography on basic pancreatic trypsin inhibitor (BPTI) immobilized to the hydroxyalkyl methacrylate copolymer Separon HEMA 1000 E is reported. Its advantage is the possibility of obtaining serine proteinases without an artificial alteration in relative molecular mass.

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