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Updated: Aug 14, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Cellular and molecular advances in elucidating p53 function

J W Shay1, H Werbin, W D Funk

  • 1University of Texas Southwestern Medical Center, Department of Cell Biology and Neurosciences, Dallas 75235-9039.

Mutation Research
|August 1, 1992
PubMed

Insights

Mutations in the p53 gene are common in human tumors and impact cancer development. Research explores p53

Area of Science:

  • Molecular Biology
  • Oncology
  • Cancer Genetics

Background:

  • Allelic loss and mutations in the p53 gene are frequently observed in human tumors.
  • These genetic alterations in p53 are implicated in multi-stage carcinogenesis.
  • The p53 gene has garnered significant research interest due to its role in cancer.

Purpose of the Study:

  • To review recent experimental findings on the role and regulation of the p53 gene.
  • To discuss the implications of p53 alterations in human tumorigenesis.
  • To explore the mechanisms by which p53 function is regulated and its role in cellular processes.

Main Methods:

  • Review of experimental data concerning p53 function and regulation.
  • Analysis of p53 mutations in human tumors and cell lines.
  • Investigation of p53 protein interactions, conformational states, and localization signals.

Main Results:

  • p53 functions as an anti-proliferative agent.
  • Specific p53 mutations are identified in various human tumors and cell lines.
  • p53 acts as a transcriptional activator, binding to specific DNA sequences.

Conclusions:

  • Understanding p53's role, regulation, and mutations is crucial for cancer research.
  • Abrogation of p53 function is important for overcoming cellular senescence.
  • Further research into p53 is vital for developing cancer therapies.

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