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Vinblastine treatment induces dose-dependent increases in the frequency of micronuclei in mouse bone marrow
1Department of Radiobiology, Kasturba Medical College, Manipal, India.
Mutation Research
|August 1, 1992
Abstract:
The effect of various doses (0.005-2.0 mg/kg b.w.) of vinblastine sulfate (VBL) was studied on the induction of micronuclei in polychromatic and normochromatic erythrocytes (PCE, NCE) of the bone marrow of female BALB/c mice. VBL treatment resulted in a dose-dependent increase in the frequency of micronucleated PCE and NCE, while the PCE/NCE ratio and mitotic index declined with increasing drug dose. The dose-effect curves were linear quadratic for all the parameters studied.
