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Inhibition of recA induction by the radioprotector 2-mercaptoethylamine
M Näslund1, A Kolman, L Ehrenberg
1Department of Radiobiology, Stockholm University, Sweden.
Mutation Research
|July 1, 1992
Abstract:
Our earlier finding that the radioprotective action of 2-mercaptoethylamine (MEA) is counteracted by ascorbate suggests a biochemical mechanism of action, which is supported by observations that MEA is not radioprotective in Rec- E. coli strains. In this study we show that MEA inhibits the induction of the recA gene by UV- or gamma-irradiation or by nalidixic acid in Escherichia coli strain GE94, which contains a recA-lacZ fusion. This effect, which may be counteracted by cysteine, indicates that in general MEA inhibits the induction of SOS functions.