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Characterization of a HeLa cDNA clone encoding the human SII protein, an elongation factor for RNA polymerase II
H C Chen1, L England, C M Kane
1Division of Biochemistry and Molecular Biology, University of California, Berkeley 94720.
Gene
|July 15, 1992
Abstract:
We present the cloning and sequence characterization of a HeLa cDNA encoding the SII transcription elongation factor. This cDNA clone is distinct from those previously isolated from a human kidney cDNA library [Yoo et al., Nucleic Acids Res. 19 (1991) 1073-1079]. Southern analysis suggests that more than one gene may exist for SII in the human genome. A comparison of deduced amino acid sequences for SII-related proteins from a variety of eukaryotes demonstrates very high similarity, especially within the C-terminal domain.