Related Experiment Video

Updated: Aug 17, 2026

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers
15:42

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers

Published on: March 6, 2009

HLA antigen studies in a family with C2 deficiency

G Opelz, M M Glovsky

    Journal of Immunogenetics
    |October 1, 1976
    PubMed

    Abstract:

    Two children in a family were found to be homozygous for C2 deficiency; both parents and a third child were heterozygous. C2 deficiency was associated with the HLA haplotypes carrying the antigens B18 and DW2. Antigen A10 was absent in this family. Mixed lymphocyte culture studies among the family members confirmed the association of C2 deficiency with the HLA-D locus.

    More Related Videos

    High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
    07:26

    High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

    Published on: July 18, 2017

    Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
    08:07

    Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

    Published on: September 6, 2017

    Related Experiment Videos

    Last Updated: Aug 17, 2026

    Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers
    15:42

    Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers

    Published on: March 6, 2009

    High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
    07:26

    High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

    Published on: July 18, 2017

    Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
    08:07

    Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

    Published on: September 6, 2017

    Related Concept Videos

    Antigens Involved in Adaptive Immunity01:26

    Antigens Involved in Adaptive Immunity

    An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
    Complete Antigens
    Complete antigens possess both immunogenicity and reactivity.
    Cytomegalovirus Disease01:27

    Cytomegalovirus Disease

    Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

    Articles linked to this work by shared authors, journal, and citation graph.

    Increased natural killer cell subsets with inhibitory cytokines and inhibitory surface receptors in patients with recurrent miscarriage and decreased or normal subsets in kidney transplant recipients late post-transplant.

    Clinical and experimental immunology·2018

    Association of pre- and early post-transplant serum amino acids and metabolites of amino acids and liver transplant outcome.

    Transplant immunology·2017

    Assessing the impact of FoxP3 and Vav1 gene polymorphisms on kidney allograft survival.

    HLA·2017

    Association of peripheral NK cell counts with Helios+ IFN-γ- Tregs in patients with good long-term renal allograft function.

    Clinical and experimental immunology·2017

    Pre-transplant soluble CD30 in combination with total DSA but not pre-transplant C1q-DSA predicts antibody-mediated graft loss in presensitized high-risk kidney transplant recipients.

    HLA·2016

    Patients with idiopathic recurrent miscarriage show higher levels of DR+ activated T-cells that are less responsive to mitogens.

    Journal of reproductive immunology·2015

    VHDJH to JH joining is not blocked in mu-chain-producing pre-B cells, implying the breakdown of allelic exclusion.

    Journal of immunogenetics·1990

    Characterization of soluble HLA molecules in sweat and quantitative HLA differences in serum of healthy individuals.

    Journal of immunogenetics·1990

    Characterization of MHC ancestral haplotypes associated with insulin-dependent diabetes mellitus: evidence for involvement of non-HLA genes.

    Journal of immunogenetics·1990

    Increased interleukin-2 receptor affinity in normal HLA A1 B8 DR3 subjects.

    Journal of immunogenetics·1990

    Immunogenetic aspects of human thyroglobulin-reactive T cell lines and hybridomas.

    Journal of immunogenetics·1990

    Evidence against extended DR3-related haplotypes in Graves' disease.

    Journal of immunogenetics·1990

    Acrylate Patch Testing for Allergic Contact Dermatitis Over 28 Years: Hierarchical Clustering for Subgroup Analysis and Computational Optimization for Patch Test Selection.

    Dermatitis : contact, atopic, occupational, drug·2026

    Analytical validation and harmonization of activity-based protease assays: requirements for clinical translation.

    Analytical and bioanalytical chemistry·2026

    Differentiating Hepatic and Renal Toxicity Reveals CYP-Independent Mechanisms of Acetaminophen-Induced Acute Kidney Injury.

    Toxicology·2026

    Comparison of Cobas Plasma Separation Cards and Whatman filter paper cards versus conventional serum samples for anti-Trypansoma cruzi antibody detection.

    PLoS neglected tropical diseases·2026

    A dual-quenching electrochemiluminescence immunosensor based on ABEI@Fe3O4@PDA-PdPt and Cu2-xS nanoflowers for sensitive detection of galectin-3.

    Mikrochimica acta·2026

    Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech.

    Chembiochem : a European journal of chemical biology·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies
    Jove
    Visualize
    Contact Us