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Some properties of selenoprotein P
1Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Biological Trace Element Research
|April 1, 1992
Summary
Selenoprotein P is a newly identified protein containing multiple selenocysteines. Its levels in plasma change with selenium status, but its exact function remains unknown.
Area of Science:
- Biochemistry
- Molecular Biology
- Nutritional Science
Background:
- Selenoprotein P is a recently identified selenoprotein.
- It is the first described protein to contain multiple selenocysteine residues.
- This protein is secreted by the liver into the bloodstream and has a rapid turnover rate.
Purpose of the Study:
- To characterize the newly identified selenoprotein P.
- To investigate the relationship between selenoprotein P concentration and selenium status.
- To explore the potential function of selenoprotein P.
Main Methods:
- Protein characterization techniques.
- Plasma concentration measurements.
- Selenium status assessment in animal models.
Main Results:
- Selenoprotein P was identified as a novel selenoprotein with multiple selenocysteines.
- Plasma concentration of selenoprotein P was found to be sensitive to the selenium status of the animal.
- The specific function of selenoprotein P could not be determined from this study.
Conclusions:
- Selenoprotein P is a unique selenoprotein with potential roles in selenium transport or metabolism.
- Its concentration serves as a biomarker for selenium nutritional status.
- Further research is needed to elucidate the precise biological function of selenoprotein P.