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[Changes in lymph microcirculation in appendicular peritonitis].

I V Iarema, V V Evdokimov, V V Eshchenko

    Rossiiskii Meditsinskii Zhurnal : Organ Ministerstva Zdravookhraneniia RSFSR
    |January 1, 1992
    PubMed
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    Appendicular peritonitis (AP) impairs microlymphatic channels but activates lymphatic drainage. Developed correction methods targeting microcirculation, the affected organ, and the lymphatic system proved effective in clinical trials, even for severe AP cases.

    Area of Science:

    • Gastroenterology
    • Surgical Pathology
    • Lymphology

    Background:

    • Appendicular peritonitis (AP) is a severe abdominal condition.
    • Understanding the impact of AP on the lymphatic system is crucial for effective treatment.

    Purpose of the Study:

    • To investigate the changes in microlymphatic channels and lymphatic drainage during appendicular peritonitis.
    • To develop and evaluate methods for correcting AP-induced microlymphocirculation abnormalities.

    Main Methods:

    • Experimental study in 63 dogs and clinical study in 116 patients.
    • Development of multi-level correction methods impacting microcirculation, the affected organ, and the lymphatic system.

    Main Results:

    • AP was found to impair microlymphatic channels.

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  • Lymphatic drainage of large-molecular substances and metabolites from the abdominal cavity was activated in AP.
  • Developed correction methods demonstrated efficacy in clinical trials, including severe AP cases.

    • Conclusions:

    • Appendicular peritonitis significantly affects microlymphatic function.
    • A comprehensive, multi-level approach to correcting microlymphocirculation abnormalities is effective in managing AP.
    • The developed methods offer a promising therapeutic strategy for appendicular peritonitis.