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Related Experiment Videos

[Binding of LPS to CD14].

U Grunwald1, G Oeser, H D Schröder

  • 1Abteilung Medizinische Immunologie, Universität Greifswald.

Immunitat Und Infektion
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Cluster of differentiation 14 (CD14), a monocyte surface glycoprotein, acts as an endotoxin receptor. Its binding to lipopolysaccharide (LPS) is facilitated by LPS-binding protein (LBP) in serum.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • CD14 (cluster of differentiation No. 14) is a 53 kDa glycoprotein found on monocyte surfaces.
  • It was identified in 1990 as a key receptor for endotoxin.

Purpose of the Study:

  • To elucidate the mechanism of endotoxin binding to CD14.
  • To understand the role of serum proteins in this interaction.

Main Methods:

  • Monoclonal antibody characterization of CD14.
  • Functional assays investigating endotoxin-CD14 interaction.

Main Results:

  • CD14 functions as an endotoxin receptor on monocytes.
  • LPS-binding protein (LBP) in serum mediates endotoxin binding to CD14.

Conclusions:

  • CD14 is crucial for monocyte recognition of endotoxins.
  • LBP is essential for the CD14-mediated endotoxin binding pathway.