Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple congenital coagulation deficiencies.

J A BONNIN, N D HICKS, M D INNIS

    Journal of Clinical Pathology
    |July 1, 1960
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Inverse design of microcavities for fluorescent excitation and collection using Lorentz reciprocity and topology optimisation.

    Optics express·2026
    Same author

    Microscopic Imaging of the Stress Tensor in Diamond Using in Situ Quantum Sensors.

    Nano letters·2019
    Same author

    The Treatment of Hydrocephalus by Ventriculo-Atrial Shunt1.

    The Australian and New Zealand journal of surgery·2017
    Same author

    Detection of nanoscale electron spin resonance spectra demonstrated using nitrogen-vacancy centre probes in diamond.

    Nature communications·2016
    Same author

    Dynamic stabilization of the optical resonances of single nitrogen-vacancy centers in diamond.

    Physical review letters·2012
    Same author

    High spatial and temporal resolution wide-field imaging of neuron activity using quantum NV-diamond.

    Scientific reports·2012
    Same journal

    Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review.

    Journal of clinical pathology·2026
    Same journal

    MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion.

    Journal of clinical pathology·2026
    Same journal

    Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall.

    Journal of clinical pathology·2026
    Same journal

    MRI-targeted versus systematic needle core biopsies in prostate cancer: a patient-based analysis of potential diagnostic and biologic underestimation.

    Journal of clinical pathology·2026
    Same journal

    Basal plasmacytosis and eosinophilia for distinguishing inflammatory bowel disease from gastrointestinal tuberculosis on mucosal biopsy.

    Journal of clinical pathology·2026
    Same journal

    Assay-dependent variability in free thyroxine (FT4): differential interference related to immunoassay design in a patient with subclinical hypothyroidism.

    Journal of clinical pathology·2026
    See all related articles

    A congenital hemorrhagic disorder led to an infant's death from subdural hemorrhage after mild trauma. Investigations revealed deficiencies in clotting factors VII and Christmas factor.

    Area of Science:

    • Pediatric Hematology
    • Congenital Bleeding Disorders

    Background:

    • Congenital hemorrhagic disorders can present with severe complications, even after minor trauma.
    • Subdural hemorrhage is a critical manifestation in infants with undiagnosed bleeding diatheses.

    Purpose of the Study:

    • To report a fatal case of congenital hemorrhagic disorder in an infant.
    • To identify the specific clotting factor deficiencies responsible for the hemorrhage.

    Main Methods:

    • Case presentation of a 6-week-old infant with fatal subdural hemorrhage.
    • Hematological investigations including clotting factor assays.

    Main Results:

    • The infant suffered from a congenital hemorrhagic disorder.
    • Deficiencies in clotting factor VII and Christmas factor (Factor IX) were identified.
    Keywords:
    BLOOD COAGULATIONHEMOPHILIA/in infancy and childhood

    Related Experiment Videos

  • A probable deficiency in Prower-Stuart factor (Factor X) was suggested but not definitively confirmed.

    • Conclusions:

    • Severe congenital deficiencies in multiple clotting factors can lead to life-threatening hemorrhage in infants.
    • Prompt hematological evaluation is crucial for diagnosing and managing congenital bleeding disorders in pediatric patients.