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The frequencies of constitutional chromosome abnormalities in an apparently normal adult population
1Genetics Unit, Geoffrey Schofield Laboratories, British Nuclear Fuels plc, Cumbria, UK.
Mutation Research
|September 1, 1992
Abstract:
Constitutional karyotypes were determined in 1405 apparently normal adults referred for population studies of acquired chromosome abnormalities in peripheral blood lymphocytes. A total of 7 translocations (4 reciprocal, 3 Robertsonian), 1 extra structurally abnormal chromosome, 2 47,XXY and 12 inv(9) were detected. An examination of previous population studies illustrates the importance of considering differences in the resolution of the chromosome analysis when comparing frequencies of abnormalities.