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Impairment of cerebral biogenic amine synthesis in a patient receiving high-dose methotrexate
F Millot1, J L Dhondt, J M Hayte
1Service d'Hématologie clinique, Centre Hospitalier, France.
The American Journal of Pediatric Hematology/Oncology
|August 1, 1992
Abstract:
A transient acute neurologic syndrome occurred in a 15-year-old boy receiving high-dose methotrexate (MTX) for acute lymphoblastic leukemia. Cerebrospinal fluid analysis revealed a decrease of homovanillic acid and 5-hydroxyindoleacetic acid concentrations with a rise of biopterin levels. These findings suggest that MTX can induce a transient alteration of the metabolism of tetrahydrobiopterin leading to the defect of biogenic amine neurotransmitter synthesis.