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Coagulation dynamics after hemodilution with polyhemoglobin.

H W Kim1, H Stubdal, A G Greenburg

  • 1Department of Surgery, Miriam Hospital, Providence, Rhode Island 02906.

Surgery, Gynecology & Obstetrics
|September 1, 1992
PubMed
Summary
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Polyhemoglobin solution (PHS) did not significantly alter blood coagulation in rats during hemodilution. While PHS slightly reduced clot strength, it did not cause significant coagulopathy, indicating its potential safety as an erythrocyte substitute.

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Toxicology

Background:

  • Erythrocyte cell substitutes are crucial for transfusion medicine.
  • Polyhemoglobin solution (PHS) is a candidate for such applications.
  • Understanding its effect on blood coagulation is vital for safety assessment.

Purpose of the Study:

  • To investigate the impact of polyhemoglobin solution (PHS) on blood coagulation.
  • To evaluate PHS's safety as a potential erythrocyte substitute in hemodilution models.

Main Methods:

  • In vitro and in vivo hemodilution studies were conducted using Sprague-Dawley rats.
  • Whole blood samples were diluted with PHS, stroma-free hemoglobin (SFH), albumin (ALB), or saline.
  • Thrombelastography (TEG) was used to analyze coagulation parameters (r, k, Ma, fi).

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Main Results:

  • PHS did not cause significant alterations in the initial coagulation mechanism at 50% hemodilution (p > 0.05).
  • SFH slightly accelerated coagulation (p < 0.05).
  • A decrease in clot tensile strength (Ma) with PHS was observed, attributed to dilution effects (p < 0.05).

Conclusions:

  • PHS appears safe at moderate hemodilution (50%) in a rat model.
  • It does not induce significant coagulopathy.
  • PHS shows potential as a safe erythrocyte substitute.