Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in Ca(2+)-binding proteins in human neurodegenerative disorders.

C W Heizmann1, K Braun

  • 1Dept of Pediatrics, University of Zurich, Switzerland.

Trends in Neurosciences
|July 1, 1992
PubMed
Summary

Calcium-binding proteins are vital neuronal markers and may protect neurons. Studying their changes in neurodegenerative diseases could reveal therapeutic targets for preventing brain damage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Riboflavin deficiency in pregnancy; its relationship to the course of pregnancy and to the condition of the foetus.

The Journal of obstetrics and gynaecology of the British Empire·2010
Same author

Hematologic observations in a case of kala-azar.

Blood·2010
Same author

Clinical and roentgenological observations in pulmonary heart disease.

Harefuah·2010
Same author

Pulmonary osteoarthropathy.

Harefuah·2010
Same author

Occurrence of phthalates in surface runoff, untreated and treated wastewater and fate during wastewater treatment.

Chemosphere·2010
Same author

Tailoring gold nanostructures for near-field optical applications.

Nanotechnology·2010

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Cellular distribution of calcium-binding proteins (CaBPs) is crucial for understanding brain function.
  • CaBPs play key roles in calcium buffering, transport, and enzyme regulation.
  • Impaired calcium homeostasis is linked to cellular degeneration, suggesting a protective role for CaBPs.

Purpose of the Study:

  • To review the role of CaBPs in neuronal function and neurodegenerative diseases.
  • To explore the potential of CaBPs as biomarkers for brain damage.
  • To identify CaBP-expressing neuronal systems as potential therapeutic targets.

Main Methods:

  • Literature review of studies on CaBP distribution and expression.
  • Analysis of CaBP changes in neurodegenerative conditions like Alzheimer's, Parkinson's, and epilepsy.

Related Experiment Videos

  • Discussion of the functional implications of CaBP alterations.

    • Main Results:

    • CaBPs serve as valuable neuronal markers for functional brain systems.
    • Changes in CaBP expression are observed in neurodegenerative diseases, though data can be inconsistent.
    • Quantification of CaBPs can help estimate the location and extent of brain damage.

    Conclusions:

    • CaBPs are important for neuronal health and function.
    • Further research into CaBP physiology may lead to novel therapeutic strategies.
    • Targeting CaBP-expressing neurons could offer a way to prevent neuronal death in neurodegenerative diseases.