Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Motor unit function during evolution of proximal axonal swellings.

D A Delio1, M G Fiori, H E Lowndes

  • 1Department of Pharmacology and Toxicology, College of Pharmacy, Rutgers University, Piscataway, NJ 08855-0789.

Journal of the Neurological Sciences
|May 1, 1992
PubMed
Summary

beta,beta'-Iminodipropionitrile (IDPN) causes motor axon swelling, impairing neurofilament transport and motor unit function. This IDPN-induced neuropathy in cats shows electrophysiological similarities to motor neuron diseases like ALS.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Methylmercury alters Eph and ephrin expression during neuronal differentiation of P19 embryonal carcinoma cells.

Neurotoxicology·2005
Same author

Domenico Battini and his description of congenital megacolon: a detailed case report one century before Hirschsprung.

Journal of the peripheral nervous system : JPNS·2000
Same author

Distribution and induction of cytochrome P450 1A1 and 1A2 in rat brain.

Toxicology and applied pharmacology·1998
Same author

Methamphetamine-induced modification of dopamine metabolism in cultured striatal astrocytes.

Pharmacology & toxicology·1998
Same author

Opioid peptide gene expression in the primary hereditary cardiomyopathy of the Syrian hamster. I. Regulation of prodynorphin gene expression by nuclear protein kinase C.

The Journal of biological chemistry·1997
Same author

Muscle fiber splitting, capillary internalization, and target-like fiber formation in familial amyloidotic polyneuropathy.

Clinical neuropathology·1996

Area of Science:

  • Neuroscience
  • Motor Neuron Biology
  • Neuropathology

Background:

  • beta,beta '-Iminodipropionitrile (IDPN) induces proximal axonal swellings in motor neurons, mimicking features of motor neuron diseases like ALS.
  • Understanding the functional consequences of these swellings is crucial for elucidating disease mechanisms.

Purpose of the Study:

  • To assess motor unit susceptibility to IDPN-induced axonal swelling.
  • To determine if functional changes in IDPN neuropathy share electromyographic features with ALS.

Main Methods:

  • Cats were administered IDPN weekly for 7, 14, or 35 days.
  • Medial gastrocnemius motoneurons and motor unit contractile responses were examined.
  • Electrophysiological properties and muscle fiber morphometry were analyzed.

Related Experiment Videos

Main Results:

  • Conduction velocities decreased, with greater slowing in fast fatigable motor units.
  • Loss of normal correlations between axonal conduction velocity, input resistance, and rheobase.
  • Early decline in fast-fatigable motor unit tension; later decline in fatigue-resistant units.
  • Development of slow and fatigable (SF) motor units and conduction block observed.
  • Type I muscle fiber atrophy occurred, reversing after IDPN cessation.

Conclusions:

  • IDPN neuropathy progressively impairs motor unit function, affecting different motor unit types differentially.
  • Electrophysiological alterations in IDPN-treated animals resemble those seen in motoneuron diseases.
  • Proximal axonal swellings significantly influence motor unit electrophysiology and contractile properties.