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12-O-tetradecanoylphorbol 13-acetate induced differentiation in human lung squamous carcinoma cells
G J Rabiasz1, S P Langdon, L Anderson
1ICRF Medical Oncology Unit, Western General Hospital, Edinburgh, UK.
British Journal of Cancer
|September 1, 1992
Abstract:
Three human lung squamous carcinoma cell lines (NX002, CX140 and CX143) demonstrate features of squamous differentiation including involucrin synthesis and competence to form cornified envelopes. 12-O-Tetradecanoylphorbol 13-acetate inhibits growth of these cell lines and this growth inhibition is associated with enhanced differentiation.