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Adenosine increases total venous capacitance in awake instrumented rats.
M R Glick1, J D Gehman, J A Gascho
1Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Journal of Cardiovascular Pharmacology
|May 1, 1992
Summary
Intravenous adenosine increases venous capacitance in rats, as shown by a dose-related decrease in mean circulatory filling pressure (MCFP). This effect occurs both with and without ganglionic blockade, indicating adenosine
Area of Science:
- Cardiovascular Physiology
- Pharmacology
Background:
- The venous system plays a crucial role in regulating circulatory dynamics.
- Adenosine's effects on venous capacitance are not fully understood.
Purpose of the Study:
- To investigate the impact of intravenous adenosine on the venous system.
- To determine if adenosine affects venous capacitance.
Main Methods:
- Mean circulatory filling pressure (MCFP) was measured in awake rats.
- Adenosine was infused intravenously at varying doses.
- Experiments were conducted before and during ganglionic blockade with hexamethonium.
Main Results:
- Adenosine caused a dose-related decrease in MCFP in both unblocked and blocked states.
- This decrease in MCFP indicates an increase in venous capacitance.
- Mean arterial pressure decreased with adenosine and hexamethonium; heart rate changes varied.
Conclusions:
- Intravenous adenosine increases venous capacitance in rats.
- The effect of adenosine on venous capacitance is independent of ganglionic blockade.