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Related Experiment Videos

Translocation t(11;14)(q13;q32) in chronic lymphoid disorders.

V Brito-Babapulle1, J Ellis, E Matutes

  • 1Academic Department of Haematology, Institute of Cancer Research, London, United Kingdom.

Genes, Chromosomes & Cancer
|September 1, 1992
PubMed
Summary
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The t(11;14) chromosomal translocation is linked to mature B-cell leukemias, particularly those with lymphoplasmacytic features. This finding aids in classifying B-cell disorders more precisely.

Area of Science:

  • Hematology
  • Oncology
  • Cytogenetics

Background:

  • The t(11;14)(q13;q32) translocation involves the BCL1 oncogene and is associated with B-lymphoproliferative disorders.
  • This abnormality may define specific lymphoma subtypes, necessitating reevaluation of its significance in B-cell malignancies.
  • Objective classification using morphology, histology, and immunophenotype is crucial for understanding B-cell disorders.

Purpose of the Study:

  • To reexamine the significance of the t(11;14) translocation in B-cell disorders.
  • To correlate the t(11;14) abnormality with specific subtypes of B-cell leukemias.
  • To assess the utility of morphology and immunophenotype in conjunction with cytogenetics for disease classification.

Main Methods:

  • Analysis of 90 patients with chronic lymphoid disorders exhibiting clonal chromosome abnormalities.

Related Experiment Videos

  • Detailed cytogenetic analysis to detect the t(11;14)(q13;q32) translocation.
  • Morphological and immunophenotypic assessment of leukemic cells.

    • Main Results:

    • The t(11;14) translocation was identified in 16 out of 90 patients.
    • The translocation was present in leukemic B-cell disorders including B-prolymphocytic leukemia, chronic lymphocytic leukemia with prolymphocytes, intermediate non-Hodgkin lymphoma, lymphoplasmacytic lymphoma, and splenic lymphoma with villous lymphocytes.
    • Notably, t(11;14) was absent in chronic lymphocytic leukemia and hairy cell leukemia.
    • Morphological and immunophenotypic analysis indicated lymphoplasmacytic features in cases with t(11;14).

    Conclusions:

    • The t(11;14) translocation is a recurrent abnormality in leukemias of mature B cells.
    • This translocation is particularly associated with B-cell leukemias exhibiting lymphoplasmacytic differentiation.
    • Cytogenetic findings combined with morphology and immunophenotype enhance the classification of B-cell lymphoproliferative disorders.