Atomic force microscopy of conventional and unconventional nucleic acid structures

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Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
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Published on: April 12, 2019

E Henderson1

  • 1Department of Zoology and Genetics, Iowa State University, Ames 50011.

Journal of Microscopy
|July 1, 1992
PubMed

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Atomic Force Microscopy

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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DNA has a double-helix structure. The...