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Quinolinehydrazones as inhibitors of retroviral reverse transcriptase
C Bartolucci1, L Cellai, P Di Filippo
1Instituto di Strutturistica Chimica G. Giacomello, C.N.R., Roma.
Farmaco (Societa Chimica Italiana : 1989)
|June 1, 1992
Abstract:
The inhibitory activity of a series of 2- and 4-quinolinehydrazones on retroviral reverse transcriptase has been studied on enzymes from M-MuLV, RAV-2, and on a crude lysate of HIV-1, assuming the first two enzymes as potential models of the third. The highest activity is mainly found in lipophilic, water soluble 4-quinolinehydrazones. The inhibitory activity of these compounds decreases in changing from the M-MuLV to the RAV-2, and HIV-1 enzymes, in this order.