Related Experiment Videos
Feto-maternal interaction of IGF-I and its binding proteins in fetal growth
M Iwashita1, M Kobayashi, A Matsuo
1Maternal and Perinatal Center, Tokyo Women's Medical College, Japan.
Early Human Development
|June 1, 1992
Abstract:
Elevated levels of maternal IGF-I and IGF-binding proteins IGFBP-1 are regulated by placental hormones rather than pituitary control during pregnancy. Maternal IGF-I promotes fetal growth by stimulating nutrient transfer to fetus through placenta and IGFBP-1 suppresses fetal growth by inhibiting IGF-I binding to receptors in placenta. Since IGF-I and IGFBP-1 are produced in placenta and decidua, respectively, fetal growth is regulated by these substances in the locally formed paracrine system.